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tyrobetaine mic  (ATCC)


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    Structured Review

    ATCC tyrobetaine mic
    Structure elucidation of <t>tyrobetaine</t> and chlorotyrobetaine. (a) The structure of tyrobetaine and chlorotyrobetaine with key NMR correlations indicated. (b) The MS2 spectrum for tyrobetaine with key masses indicated. *Indicates the mass after removal of the trimethylammonium. LOH = hydroxyleucine. Red masses indicate observed masses. Δppm values are indicated in parentheses after the key masses. Key mass losses are in purple.
    Tyrobetaine Mic, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1832 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tyrobetaine mic/product/ATCC
    Average 99 stars, based on 1832 article reviews
    tyrobetaine mic - by Bioz Stars, 2026-03
    99/100 stars

    Images

    1) Product Images from "Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics"

    Article Title: Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

    Journal: ACS chemical biology

    doi: 10.1021/acschembio.7b01089

    Structure elucidation of tyrobetaine and chlorotyrobetaine. (a) The structure of tyrobetaine and chlorotyrobetaine with key NMR correlations indicated. (b) The MS2 spectrum for tyrobetaine with key masses indicated. *Indicates the mass after removal of the trimethylammonium. LOH = hydroxyleucine. Red masses indicate observed masses. Δppm values are indicated in parentheses after the key masses. Key mass losses are in purple.
    Figure Legend Snippet: Structure elucidation of tyrobetaine and chlorotyrobetaine. (a) The structure of tyrobetaine and chlorotyrobetaine with key NMR correlations indicated. (b) The MS2 spectrum for tyrobetaine with key masses indicated. *Indicates the mass after removal of the trimethylammonium. LOH = hydroxyleucine. Red masses indicate observed masses. Δppm values are indicated in parentheses after the key masses. Key mass losses are in purple.

    Techniques Used:

    Tyrobetaine BGC and heterologous expression. (a) The BGC for the tyrobetaines from Streptomyces sp. WC-3703. Arrows indicate genes. The color of the arrow corresponds to the type of gene (indicated below the arrows). See Table S5 for BLAST analysis. (b) AntiSMASH NRPS domain predictions for TybD, TybE, and TybF. A = adenylation domain with subscript indicating the predicted amino acid (Y = tyrosine, X = no consensus, A = alanine). MT = N-methyltransferase. T = thiolation domain. C = condensation domain. See Table S6 for NRPS adenylation domain predictions. (c) Extracted ion chromatogram for tyrobetaine (587.30–587.31) in wild type S. lividans 66, S. lividans 66 pRAM6 (heterologous expression of NRPS_GCF.432), purified tyrobetaine, and S. lividans 66 pRAM6 spiked with purified tyrobetaine.
    Figure Legend Snippet: Tyrobetaine BGC and heterologous expression. (a) The BGC for the tyrobetaines from Streptomyces sp. WC-3703. Arrows indicate genes. The color of the arrow corresponds to the type of gene (indicated below the arrows). See Table S5 for BLAST analysis. (b) AntiSMASH NRPS domain predictions for TybD, TybE, and TybF. A = adenylation domain with subscript indicating the predicted amino acid (Y = tyrosine, X = no consensus, A = alanine). MT = N-methyltransferase. T = thiolation domain. C = condensation domain. See Table S6 for NRPS adenylation domain predictions. (c) Extracted ion chromatogram for tyrobetaine (587.30–587.31) in wild type S. lividans 66, S. lividans 66 pRAM6 (heterologous expression of NRPS_GCF.432), purified tyrobetaine, and S. lividans 66 pRAM6 spiked with purified tyrobetaine.

    Techniques Used: Expressing, Purification

    Feeding experiments with stable isotope labeled amino acids. Mass spectrum from spent media from Streptomyces sp. NRRL WC-3703 grown on (a) medium alone or medium with (b) D4-L-tyrosine, (c) D3,13C-methionine, (d) D10-L-leucine, or (e) D4-L-alanine. (f) Structure of tyrobetaine with likely location of stable isotopes. Yellow bar indicates the m/z for tyrobetaine. Colored bars indicate isotopically labeled tyrobetaine. See Figure S6 for chlorotyrobetaine.
    Figure Legend Snippet: Feeding experiments with stable isotope labeled amino acids. Mass spectrum from spent media from Streptomyces sp. NRRL WC-3703 grown on (a) medium alone or medium with (b) D4-L-tyrosine, (c) D3,13C-methionine, (d) D10-L-leucine, or (e) D4-L-alanine. (f) Structure of tyrobetaine with likely location of stable isotopes. Yellow bar indicates the m/z for tyrobetaine. Colored bars indicate isotopically labeled tyrobetaine. See Figure S6 for chlorotyrobetaine.

    Techniques Used: Labeling

    Antibiotic Activity, Anticancer Activity, and Protease Inhibition of Tyrobetaine and Chlorotyrobetaine a
    Figure Legend Snippet: Antibiotic Activity, Anticancer Activity, and Protease Inhibition of Tyrobetaine and Chlorotyrobetaine a

    Techniques Used: Activity Assay, Inhibition



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    tyrobetaine mic  (ATCC)
    99
    ATCC tyrobetaine mic
    Structure elucidation of <t>tyrobetaine</t> and chlorotyrobetaine. (a) The structure of tyrobetaine and chlorotyrobetaine with key NMR correlations indicated. (b) The MS2 spectrum for tyrobetaine with key masses indicated. *Indicates the mass after removal of the trimethylammonium. LOH = hydroxyleucine. Red masses indicate observed masses. Δppm values are indicated in parentheses after the key masses. Key mass losses are in purple.
    Tyrobetaine Mic, supplied by ATCC, used in various techniques. Bioz Stars score: 99/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/result/tyrobetaine mic/product/ATCC
    Average 99 stars, based on 1 article reviews
    tyrobetaine mic - by Bioz Stars, 2026-03
    99/100 stars
    		  Buy from Supplier

    Image Search Results


    Structure elucidation of tyrobetaine and chlorotyrobetaine. (a) The structure of tyrobetaine and chlorotyrobetaine with key NMR correlations indicated. (b) The MS2 spectrum for tyrobetaine with key masses indicated. *Indicates the mass after removal of the trimethylammonium. LOH = hydroxyleucine. Red masses indicate observed masses. Δppm values are indicated in parentheses after the key masses. Key mass losses are in purple.

    Journal: ACS chemical biology

    Article Title: Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

    doi: 10.1021/acschembio.7b01089

    Figure Lengend Snippet: Structure elucidation of tyrobetaine and chlorotyrobetaine. (a) The structure of tyrobetaine and chlorotyrobetaine with key NMR correlations indicated. (b) The MS2 spectrum for tyrobetaine with key masses indicated. *Indicates the mass after removal of the trimethylammonium. LOH = hydroxyleucine. Red masses indicate observed masses. Δppm values are indicated in parentheses after the key masses. Key mass losses are in purple.

    Article Snippet: We expect that tyrobetaine does have a biological function that we have yet to discover. table ft1 table-wrap mode="anchored" t5 caption a7 organism/protease tyrobetaine MIC b or IC 50 c ( μ M) chlorotyrobetaine MIC b or IC 50 c ( μ M) oxytetracycline MIC ( μ g/mL) oxytetracycline + 32 μ g/mL tyrobetaine MIC ( μ g/mL) E. faecalis ATTC 19433 >100 >100 ND ND S. aureus ATCC 29213 >100 >100 ND ND K. pneumoniae ATCC 27736 >100 >100 ND ND A. baumannii ATCC 19606 >100 >100 ND ND P. aeruginosa PAO1 >100 >100 ND ND E. coli ATCC 25922 >100 >100 4 8 A549 human lung cancer >100 >100 ND ND ACE >10 ND ND ND HIV-1 protease >10 ND ND ND Open in a separate window a ND = not determined.

    Techniques:

    Tyrobetaine BGC and heterologous expression. (a) The BGC for the tyrobetaines from Streptomyces sp. WC-3703. Arrows indicate genes. The color of the arrow corresponds to the type of gene (indicated below the arrows). See Table S5 for BLAST analysis. (b) AntiSMASH NRPS domain predictions for TybD, TybE, and TybF. A = adenylation domain with subscript indicating the predicted amino acid (Y = tyrosine, X = no consensus, A = alanine). MT = N-methyltransferase. T = thiolation domain. C = condensation domain. See Table S6 for NRPS adenylation domain predictions. (c) Extracted ion chromatogram for tyrobetaine (587.30–587.31) in wild type S. lividans 66, S. lividans 66 pRAM6 (heterologous expression of NRPS_GCF.432), purified tyrobetaine, and S. lividans 66 pRAM6 spiked with purified tyrobetaine.

    Journal: ACS chemical biology

    Article Title: Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

    doi: 10.1021/acschembio.7b01089

    Figure Lengend Snippet: Tyrobetaine BGC and heterologous expression. (a) The BGC for the tyrobetaines from Streptomyces sp. WC-3703. Arrows indicate genes. The color of the arrow corresponds to the type of gene (indicated below the arrows). See Table S5 for BLAST analysis. (b) AntiSMASH NRPS domain predictions for TybD, TybE, and TybF. A = adenylation domain with subscript indicating the predicted amino acid (Y = tyrosine, X = no consensus, A = alanine). MT = N-methyltransferase. T = thiolation domain. C = condensation domain. See Table S6 for NRPS adenylation domain predictions. (c) Extracted ion chromatogram for tyrobetaine (587.30–587.31) in wild type S. lividans 66, S. lividans 66 pRAM6 (heterologous expression of NRPS_GCF.432), purified tyrobetaine, and S. lividans 66 pRAM6 spiked with purified tyrobetaine.

    Article Snippet: We expect that tyrobetaine does have a biological function that we have yet to discover. table ft1 table-wrap mode="anchored" t5 caption a7 organism/protease tyrobetaine MIC b or IC 50 c ( μ M) chlorotyrobetaine MIC b or IC 50 c ( μ M) oxytetracycline MIC ( μ g/mL) oxytetracycline + 32 μ g/mL tyrobetaine MIC ( μ g/mL) E. faecalis ATTC 19433 >100 >100 ND ND S. aureus ATCC 29213 >100 >100 ND ND K. pneumoniae ATCC 27736 >100 >100 ND ND A. baumannii ATCC 19606 >100 >100 ND ND P. aeruginosa PAO1 >100 >100 ND ND E. coli ATCC 25922 >100 >100 4 8 A549 human lung cancer >100 >100 ND ND ACE >10 ND ND ND HIV-1 protease >10 ND ND ND Open in a separate window a ND = not determined.

    Techniques: Expressing, Purification

    Feeding experiments with stable isotope labeled amino acids. Mass spectrum from spent media from Streptomyces sp. NRRL WC-3703 grown on (a) medium alone or medium with (b) D4-L-tyrosine, (c) D3,13C-methionine, (d) D10-L-leucine, or (e) D4-L-alanine. (f) Structure of tyrobetaine with likely location of stable isotopes. Yellow bar indicates the m/z for tyrobetaine. Colored bars indicate isotopically labeled tyrobetaine. See Figure S6 for chlorotyrobetaine.

    Journal: ACS chemical biology

    Article Title: Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

    doi: 10.1021/acschembio.7b01089

    Figure Lengend Snippet: Feeding experiments with stable isotope labeled amino acids. Mass spectrum from spent media from Streptomyces sp. NRRL WC-3703 grown on (a) medium alone or medium with (b) D4-L-tyrosine, (c) D3,13C-methionine, (d) D10-L-leucine, or (e) D4-L-alanine. (f) Structure of tyrobetaine with likely location of stable isotopes. Yellow bar indicates the m/z for tyrobetaine. Colored bars indicate isotopically labeled tyrobetaine. See Figure S6 for chlorotyrobetaine.

    Article Snippet: We expect that tyrobetaine does have a biological function that we have yet to discover. table ft1 table-wrap mode="anchored" t5 caption a7 organism/protease tyrobetaine MIC b or IC 50 c ( μ M) chlorotyrobetaine MIC b or IC 50 c ( μ M) oxytetracycline MIC ( μ g/mL) oxytetracycline + 32 μ g/mL tyrobetaine MIC ( μ g/mL) E. faecalis ATTC 19433 >100 >100 ND ND S. aureus ATCC 29213 >100 >100 ND ND K. pneumoniae ATCC 27736 >100 >100 ND ND A. baumannii ATCC 19606 >100 >100 ND ND P. aeruginosa PAO1 >100 >100 ND ND E. coli ATCC 25922 >100 >100 4 8 A549 human lung cancer >100 >100 ND ND ACE >10 ND ND ND HIV-1 protease >10 ND ND ND Open in a separate window a ND = not determined.

    Techniques: Labeling

    Antibiotic Activity, Anticancer Activity, and Protease Inhibition of Tyrobetaine and Chlorotyrobetaine a

    Journal: ACS chemical biology

    Article Title: Discovery of the Tyrobetaine Natural Products and Their Biosynthetic Gene Cluster via Metabologenomics

    doi: 10.1021/acschembio.7b01089

    Figure Lengend Snippet: Antibiotic Activity, Anticancer Activity, and Protease Inhibition of Tyrobetaine and Chlorotyrobetaine a

    Article Snippet: We expect that tyrobetaine does have a biological function that we have yet to discover. table ft1 table-wrap mode="anchored" t5 caption a7 organism/protease tyrobetaine MIC b or IC 50 c ( μ M) chlorotyrobetaine MIC b or IC 50 c ( μ M) oxytetracycline MIC ( μ g/mL) oxytetracycline + 32 μ g/mL tyrobetaine MIC ( μ g/mL) E. faecalis ATTC 19433 >100 >100 ND ND S. aureus ATCC 29213 >100 >100 ND ND K. pneumoniae ATCC 27736 >100 >100 ND ND A. baumannii ATCC 19606 >100 >100 ND ND P. aeruginosa PAO1 >100 >100 ND ND E. coli ATCC 25922 >100 >100 4 8 A549 human lung cancer >100 >100 ND ND ACE >10 ND ND ND HIV-1 protease >10 ND ND ND Open in a separate window a ND = not determined.

    Techniques: Activity Assay, Inhibition